Actin and Myosin in the Mitotic Spindle

plus end–binding protein CLASP. Mitochondrial aggregation could not be recapitulated by mutants of either the motor protein dynein or other plus end–binding proteins. The Peg1 mutation did not affect the cytoskeleton, and the changes were independent of the cell cycle, suggesting the aggregation was not due to other changes in microtubules. Peg1 was found to be a mitochondrial peripheral membrane protein. As CLASP links membranes to microtubules in mammalian cells, Chiron proposes a similar function for Peg1 in yeast, and suggests that it hitches mitochondria to microtubules. Chiron, S., et al. 2008. J. Cell Biol. doi:10.1083/jcb.200712147.